CURRICULUM VITAE du Docteur Bruno Pirenne

 

Date de naissance                 Ixelles, 19 septembre 1957

Nationalité                            Belge

Situation familiale :               Trois enfants (1990, 1991, 1995).

 

Adresse professionnelle     Clinique St Pierre - Service de Cardiologie

                                           Avenue Reine Fabiola, 1340 Ottignies

Téléphone                           010/43.73.47 (secrétariat).

                                           010/43.71.90 (direct)

Fax                                      010/437.139

                                           Bruno.pirenne@cspo.be

                                           cspo@mediren.be

                                           www.cspo.be

 

Adresse professionnelle    Centre de Cardiologie Charlemagne

                                          Avenue de l’Union Européenne, 16

                                          1348 Louvain La neuve

Téléphone                          010/23.87.11

E mail                                 dr.pirenne@cardiolln.be

                                           www.cardiolln.be

 

Sports/ Loisirs :                 Natation, randonnées, photo, musique.

 

 

 

Enseignement et Formations :

 

Enseignement universitaire et postuniversitaire:

1975 - 1982                            Université Catholique de Louvain

                                               Faculté de Médecine de Louvain-en-Woluwe, 1200 Bruxelles.

 

            Spécialisation en Cardiologie : UCL

1982 - 1983                            Clinique Sainte-Elisabeth, Namur,

                                               service de Médecine Interne (Dr. A Cuvelier),

1983 - 1984                            Centre Hospitalier de Luxembourg, Luxembourg 

                                               service de Médecine Interne (Dr. M. Dicato

1984 - 1985                            Clinique Saint-Michel, Bruxelles,

                                               service de Médecine Interne (Dr. P. Dewil),

1985 - 1986                            Clinique Saint-Jean, Bruxelles,

                                               service de Cardiologie (Dr. P. Gruwez),

1986 – 1987                           Cliniques Universitaires de Mont-Godinne

                                               service de Cardiologie (Prof. R. Kremer)

                                               Cliniques Univeristiares Saint-Luc, Bruxelles

                                               service de Cardiologie (Prof. L. Brasseur).

 

 

            Spécialisation en Soins Intensifs : UCL

1987 - 1988                            Hôpital Cantonal, Genève

                                               Division des soins intensifs chirurgicaux, (Prof. P.M. Suter).

                                               Division des soins intensifs médicaux, (Dr. J.C. Chevrolet)

1988 – 1989                           Cliniques Universitaires St-Luc, Bruxelles

                                               Département des Soins Intensifs,

                                               Unité Cardiaque Médicale et Coronarienne (Prof. J. Col)

                                               Unité de Chirurgie Cardio-thoracique (Prof. M. Goenen).

 

           Formation en éthique biomédicale

1995-2000                              Universite Catholique de Lille

                                               Centre d’Ethique Médicale, D. Jacquemin.

             Diplômes et agréation:

1982                                       Docteur en Médecine, Chirurgie et Accouchements, UCL,

1987                                       Spécialiste en Cardiologie, UCL

1989                                       Certificat de Médecine Intensive et d'Urgences, UCL

1987                                       Agréation INAMI en Cardiologie

1989                                       Agréation INAMI en Médecine Interne

1997                                       Compétence légale en Medecine Intensive, renouvellée en 2002, 2007
                                               puis à titre définitif en 2012.

 

Expérience professionnelle :

 

1989-2009 :                            Service de Soins Intensifs

                                               Clinique Saint-Pierre, 1340 Ottignies.

1990-2000 :                            Cliniques St Luc - 1200 Bruxelles

     Cardiologie interventionnelle (1demi-jour /semaine).

1999-2005 :                            Médecin Chef de Service

                                               Service de Soins Intensifs

                                               Clinique St Pierre 1340 Ottignies.

2009 – ongoing                      Activité de gardes

                                                

2009 – ongoing :                    Service de Cardiologie

                                               Clinique Saint Pierre

                                               BHC ,

2013-2016                              Coordinateur Médical

                                               Brussels - Brabant Heart Center

                                              

Expérience en cardiologie :

Coronarographie, 1990-2008, CSPO

Cardiologie Interventionnelle, UCL, 1988-2000

Echographie cardiaque (transthoracique et transoesophagienne)

Scan coronaire, 2009

Recherche clinique 1993-ongoing

 

Ethique biomédicale :

Membre du Comité d’Ethique, clinique St Pierre, 2006

Président du Comité d’Ethique, clinique St Pierre, 2013- ongoing

 

Sociétés scientifiques :

Membre correspondant de la Société Belge de Médecine Intensive, avril 1992.

Membre ordinaire de la Société Européenne de Soins Intensifs, 1996.

Membre du Belgian interdisciplinary working group on acute cardiology (BIWAC), 1998

Membre de la Société Européenne de Cardiologie, 2012

Membre de la Société Européenne de Cardiologie, heart failure association, 2008Cliniques St Luc - 1200 Bruxelle

 

 

Travaux scientifiques

 

A-Publications

1.-        Pirenne B, Marchandise B :

            Electrocardiogramme et hypothermie : à  propos d'un cas.

            Arch. Mal. Coeur. 1988.81:1017-1020.

 

2.-        Bohon Ph. Dugernier T, Debongnie JC, Pirenne B.

            Pneumopathie interstitielle d'hypersensibilité et recto-colite ulcéro-hémorragique : rôle du methotrexate.

            Acta Gastroente Bel 1993,56:352-7.

 

3.-        Col J, Pirenne B, Decoster O, Payen B, Deligne B, Purnode P, Bachy JL, Renkin J.

            Basic components and patterns of acute ischemia recovery assessed from continuous ST monitoring  in acute
            myocardial  infarction treated by thrombolytic therapy.

            Journal of Electrocardiology. 1994:27 supplement, 241-248.

 

4.-        Amrani M, Rubay J, Pirenne B, Col J, Dion R.

            Isolation of the left coronary artery ostium by an aortic cusp attachment : a rare cause of myocardial ischemia.

            Eur J Cardio-thorac Surg, 1994 8:663-664.

 

5.-        Renkin J, Pirenne B, Carlier M, Col J.

            Traitement de l'infarctus du myocarde. Thrombolyse ou angioplastie ?

            Louvain Médical 1995 114:223-6.

 

6.-        Al Shwafi K, de Meester A, Pirenne B, Renkin J, Col J :

            Rapid detection of streptokinase resistance using a bedside lytic assay of dry recipent technology.

            Fibrinolysis and Proteolysis, 2000,14(6);1-7.

 

7;-        Honoré PM, Jamez J, Wauthier M, Lee PA, Dugernier T,Pirenne B,Hanique G, Matson JR.

            Prospective evaluation of short term, high volume isovolemic hemofiltration on the hemodynamic course
            and outcome in patients with intractable circulatory failure from septic shock.

            Crit Care Med 2000 Nov;28 (11): 3581-7. 12.-    

 

8,-        R. Colenbunders, J.L. Mariage,J.CH Coche, B. Pirenne, S. Kempinaire, Ph. Hantson, A. Van Gompel,
            M. Niedrig, M. Van Esbroeck, R. Bailey, C. Drosten, and H. Scmitz:

            A belgian traveler who acquired yellow fever in the gambia.

            Clin; Infect; Dis. 2002, Nov 15;35 (10): e113-6. Epub 2002 Oct 28.

 

9,-        Kamal A. Al Shawafi, Antoine de Meester, Bruno Pirenne, Jacques J. Col.

            Comparative fibrinolytic activity of front-loaded alteplase and the single bolus mutants tenecteplase
            and lanoteplase during treatment of acute myocardial infarction.

            Am Heart J 2003; 145:217-25.

           

10.       Double-Blind Parallel Placebo-Controlled Study to Evaluate the Effect of Molsidomine on the Endothelial Dysfunction
            in Patients with Stable Angina Pectoris Undergoing Percutaneous Coronary Intervention: the MEDCOR Trial.

            Barbato E, Herman A, Benit E, Janssens L, Lalmand J, Hoffer E, Chenu P, Guédès A, Missault L, Pirenne B,
            Cardinal F, Vercauteren S, Wijns W.

            J Cardiovasc Transl Res. 2013 Oct 19. [Epub ahead of print]

 

11.       Barbato E, Herman A, Benit E, Janssens L, Lalmand J, Hoffer E, Chenu P, Guédès A, Missault L, Pirenne B,
            Cardinal F, Vercauteren S, Wijns W.

            Double-blind parallel placebo-controlled study to evaluate the effect of molsidomine on the endothelial dysfunction
            in patients with stable angina pectoris undergoing percutaneous coronary intervention: the MEDCOR Trial.

           J Cardiovasc Transl Res. 2014 Mar;7(2):226-31. doi: 10.1007/s12265-013-9513-9. Epub 2013 Oct 19.

B - Abstracts

 

1.-        Pirenne B, Bruchner JC, Suter PM :

            Intérêt de la mesure de la dépense énergétique en médecine intensive.
            Assemblée Annuelle Suisse de Médecine Intensive. Montreux, 1988.

            Schweiz. Med. Wschr 1989;119:384.

 

2.-        Palazzo M, Pirenne B, Morel DR, Suter PM :

            Relationship between O2 consumption and O2 delivery in severely ill patients with reference to their
            hormonal status and outcome.

            Assemblée Annuelle Suisse de Médecine Intensive. Montreux, 1988.

            Schweiz. Med. Wschr 1989;119:380.

 

3.-        Col J, Decoster O, Hanique G, Deligne B, Boland J, Pirenne B, Cheron P, Renkin J :

            Infusion of heparin conjunct to streptokinase accelerates reperfusion of acute myocardial infarction :
            results of double blind randomized stury (OSIRIS).

            American Heart Association, New Orleans, novembre 1992. Circulation 86, I 259, 1992.

 

4.-        Decoster O, Boland J, Pirenne B, Cheron P, Renkin J, Col J :

            Recovery patterns obtained from continuous ST segment monitoring during thrombolysis for acute myocardial
            infarction are good predictors for coronary recanalization. American College of Cardiology, Anaheim, Mars 1993.

            JACC 21,459A, 1993.

 

5.-        Decoster O, Renkin J, Boland J, Pirenne B, Cheron P, Col J.

            Recovery patterns obtained from continuous ST segment monitoring during thrombolysis for acute myocardial
            infarction are accurate Predictor for successful myocardial reperfusion.
            European Society of Cardiology, Nice, Septembre 1993.

            Eur. Heart J, 1993 14:354.

 

6.-        Col J, Al Shwafi K, Pirenne B, Renkin J, Van de Werf F.

            Analysis of continuous ST-segment monitoring  as a surrogate to coronary angiograms for assessing
            thrombolytic efficacy. Application in the GUSTO trial.
            Annual scientific meeting of the Belgian Society of Cardiology, Brussels, February 1996.

            Acta Cardiologica Belgica, 1996, 51(1), 44.

 

7.-        Al Shwafi K, Col J, Pirenne B, de Meester A, Miesse C, Renkin J :

            Lytic activity with accelerated t-PA assessed at bedside during thrombolytic therapy for acute myocardial infarction.

            JACC, 1997,29(2), 1034-54,1997.

            Thrombosis and hemostasis, 1997:suppl june:502.

 

8.-        Col J, Al Shwafi K, Pirenne B, de Meester A, Miesse C, Renkin J.

            Lytic activity profile of 1.5 MU streptokinase infused in 6O minutes for acute myocardial infarction. 
            European Society of Cardiology.

            August 24-28, 1997. Stockholm - Sweden.

            Eur. Heart Journal, 1997, 18(suppl.), 634.

 

9.-        de Meester A, Al Shwafi K, Pirenne B, Miesse C, Renkin J, Col J.

            Comparison of lytic activities during accelerated t-PA and streptokinase infusion in patients treated for acute
            myocardial infarction.
            European Society of Cardiology. August 24-28, 1997. Stockholm - Sweden.

            Eur. Heart Journal. 1997,18(suppl.),634.

 

10.-      Al Shwafi K, de Meester A, Pirenne B, Miesse C, Renkin J, Col J.

            Comparative lytic activity profiles of accelerated infusion of t-PA and 30 mgr bolus of TNK-tPA.
            European Society of Cardiology. August 24-28, 1997. Stockholm - Sweden.

            Eur. Heart Journal, 1997, 18(suppl), 633.

11.-      Al Shwafi K, de Meester A, Pirenne B, Renkin J, Col J.

            Rapid establishment of intense lytic activity with t-PA correlates with early ST elevation resolution as
            predictor of outcome after AMI.

            Circulation, 1997 : 96,8(supplément):260.

 

12.-      Vranckx P, Al Shwafi K, de Meester A, Pirenne B, Jacquet L, Renkin J, Col J.

            In vitro lytic response to 1OO U/ml streptokinase predicts ECG response to standard dose of streptokinase for AMI.

            Circulation, 1997 : 96,I 260:1445.

 

13.-      de Meester A; Al Shwafi K, Pirenne B, Vranckx P, Renkin J et Col J.

            In-vitro streptokinase resistance test for rapid prediction of coronary artery patency using continuous
            ST-segment monitoring during acute myocardial infarction.

            Acta Cardiologica Vol LII, 1997:6:556-557.

 

14.-      de Meester A; Al Shwafi K, Pirenne B, Vranckx P, Renkin J et Col J.

            The thrombolytic response early during the 60-minutes infusion of 1.5 MU streptokinase determined the extent of
            ST segment resolution in patients with acute myocardial infarction.

            Acta Cardiologica Vol LII,1997:6:543-544.

 

15.-      Al Shwafi K, de Meester A, Pirenne B, Vranckx P, Renkin J, Col J. 

            Rapid clot lysis test predicts lytic response to streptokinase therapy for acute myocardial infarction. 
            European Society of Cardiology, August, 22-26, 1998, Vienna. 

            Eur Heart J, 1998,19:280.

            J Am Coll Cardiol 1998:31, suppl C:454.

 

16.-      Al Shwafi K, de Meester A, Pirenne B et al. Rapid clot lysis test predicts lytic response to streptokinase therapy
            for acute myocardial infarction.

            J Am Coll Cardiol 1998:31:454.

 

17.-      Al Shwafi K, de Meester A, Pirenne B, Renkin J, Col J.

            Bedside lytic activity assessment during accelerated tPA and TNK-tPA therapy for acute myocardial infarction.

            J Am Coll Cardiol 1998;31:452A.

 

18.-      de Meester A, Al Shwafi K, Pirenne B et al.

            In vitro streptokinase test for rapid prediction of coronary artery patency by angiography after acute
            myocardial infarction.

            Eur Heart J 1999.

 

19.-      Al Shafi K, de Meester A, Pirenne B, Vranckx P, Renkin J, Col J.

            Evaluation of a rapid bedside test for streptokinase resistance applied in acute myocardial infarction (abstract).
            Eur Heart J 1999;20(suppl):516.

 

20.       Emanuele Barbato, Arnold Herman , Edouard Benit , Luc Janssens , Jacques Lalmand , Etienne Hoffer

            Patrick Chenu , Antoine Guedes , Luc Missault ,Bruno Pirenne , François Cardinal,  Steven Vercauteren , William Wijns .

            Long-term effect of molsidomine, a direct nitric oxide donor, as an add-on treatment, on endothelial dysfunction
            in patients with stable angina pectoris undergoing percutaneous coronary intervention: Results of the MEDCOR trial.

            Atherosclerosis 240 (2015) 351e354

 

C - Présentations

 

1.-        Cosyns J, Pirenne B, Vanoverschelde JL, Rousseau M, Wyns W, Raphael D :

            Validity of Echo-Doppler assessment of aortic stenosis.
            Its impact on decision making between surgery and valvuloplasty. 

            First Belgian Meeting on Echocardiography and Cardiac Doppler. Bruxelles, 1987.

 

2.-        Pirenne B, Vanoverschelde JL, Col J :

            Le devenir du coeur greffé et les méthodes d'évaluation de sa fonction.
            "La transplantation cardiaque à l'UCL, 1985-1990.
            Réunion trimestrielle de Cardiologie, 9 mars 1990.

 

3.-        Decoster O, Boland J, Cheron P, Pirenne B, Renkin J, Col J.

            Continuous ST segment monitoring during thrombolysis for acute myocardial infarction predicts
            accurately coronary recanalization.
            Seventh Annual Meeting of the BWGIC, Bruxelles, 1992.

 

4.-        Pirenne B, Col J :

            Monitoring du segment ST : intérêt et applications cliniques.
            Journées d'enseignement pour Paramédicaux.
            Sodehotel, Bruxelles, avril 1993.

 

5.         Col J, Pirenne B, Decoster O, Payen B, Deligne B, Purnode P, Bachy JL, Renkin J.

            Basic components and patterns of acute ischemia recovery assessed from continuous ST monitoring 
            in acute myocardial infarction treated by thrombolytic therapy. 

            International Society for Computerized Electrocardiology, Santa Barbara, U.S.A. April 28th.

 

6.-        Pirenne B :

            Monitoring ST et pathologie coronarienne aigue.
            Journée d'enseignement pour paramédicaux, Charleroi, novembre 1994.

 

7.-        Jamez J, Wauthier M, Dugernier Th, Honore P, Pirenne B, Moos B, Hassoun A.

            Haemodialysis : A new  and possible alternative therapeutic approach in acute intermittent porphyria crises.
            International association for the study of the liver. February 1996.  Cape Town, South Africa.

 

8.-        Al Swhafi K, Col J, Pirenne B, de Meester A,  Miesse C, Renkin J.

            Lytic activity with accelerated t-PA assessed at bedside during thrombolytic therapy for acute myocardial infarction. 
            Annual scientific meeting of the Belgian Society of Cardiology, Brussels, January 1997.

 

9.-        Pirenne B.
            Les syndromes coronariens aigus:
            Cycle de formation complémentaire spécialisée en soins intensifs,

            CPSI, ACN, Bruxelles, 1996-1997

 

10.-      Pirenne B :
            Thrombolyse et angioplastie coronaire,
            Cycle de formation complémentaire spécialisée en soins intensifs,

            CPSI, ACN, Bruxelles 1996-1997.

 

11.-      Pirenne B:
            Pathologie coronarienne aiguë: de la physiopathologie au traitement,
            Cycle de spécialisation en soins intensifs,

            CPSI, ACN, Bruxelles, 1996-1997.

 

12.-      Al Shwafi K, de Meester A, Pirenne B, Miesse Ch, Vranckx P, Renkin J, Col J. 

            Clinical value of a new method of thrombolytic assessment.
            Société Belge de Médecine Intensive et de Médecine d'Urgence.  May 1998.

 

13.-      Al Shwafi K, de Meester A, Pirenne B, Vranckx P, Renkin J, Col J. 

            Rapid clot lysis test predicts lytic response to streptokinase therapy for acute myocardial infarction. 
            Société Belge de Cardiologie, 5-6-7 February 1998, Brussels.

 

14.-      de Meester A, Al Shwafi K, Pirenne B, Vranckx P, Renkin J, Col J. 

            The thrombolytic response early during the 60-minutes infusion of 1,5 MU streptokinase determined
            the extent of ST segment resolution in patients with acute myocardial infarction. 

            Société Belge de Cardiologie, 5-6-7 February 1998, Brussels.

 

15.-     Pirenne B :
           Les progrès du scan coronaire dans la détection de la maladie coronaire.

           Symposium de cardiologie, BHC, Genval, 2010

 

16. -     Pirenne B. :
            Nouveautés en imagerie médicale dans les secteur cardiovasculaire. Apport du scan coronaire.

            Symposium de soins infirmiers dans le secteur cardiovasculaire, Leuven may 2012

 

 

Participation aux études cliniques : 1993-2016

 

1.-        GUSTO I :

            Global utilization of streptokinase ant t-PA for occluded arteries I.

            NEJM 1993,329:673-82.

2.-        GUSTO II :

            Global use of strategies to open occluded coronary arteries II.

            Circulation 1994;90:1631-7.

            NEJM 1996;335/775-82.

3.-        OPUS-TIMI 16 :

            Oral glycoprotein IIb/IIIa inhibition with orbofiban in patients with unstable coronary syndromes (OPUS-TIMI 16) trial.

            AHA, novembre 1999.
           Circulation. 2000 Jul 11;102(2):149-56.

4.-        IN TIME II :

            Intravenous nPA for treatment of infarcting myocardium early.

            Eur Heart J, 2000;21:2005-2013.

5.-        ASSENT 2 TRIAL

    Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction:
    The ASSENT-2 double-blind randomised trial.

    Lancet.
1999 Aug 28;354(9180):716-22.

 

6.-        EXTRACT–TIMI 25

            Enoxaparin andThrombolysis Reperfusion for AcuteMyocardial Infarction Treatment
            Thrombolysis in Myocardial Infarction 25.

            NEJM,2006, 1-12

7.         OAT trial:

            Coronary intervention for persistent occlusion after myocardial infarction

            N Engl J Med. 2006 Dec 7;355(23):2395-407. Epub 2006 Nov 14.

8.-        MERLIN-TIMI 36

            Effects of Ranolazine on Recurrent Cardiovascular Events in Patients With Non–ST-Elevation acute coronary syndromes

            JAMA. 2007;297(16):1775-1783

9.-        IMPROVE-IT trial : investigateur principal
            A multicenter, double blind, randomized study to establish the clinical benefit and safety of Vytorin
            (Ezetimibe/simvastatin tablet) vs Simvastatin monotherapy in high risk subjects presenting
            with acute coronary syndrome.

   ongoing

   Schering-Plough 2009

10.-      PEGASUS TIMI 54  trial: investigateur principal
            A Randomized, Double-Blind, Placebo Controlled, Parallel Group, Multinational Trial,
            to Assess the Prevention of Thrombotic Events with Ticagrelor Compared to Placebo on a Background
            of Acetyl Salicylic Acid (ASA) Therapy in Patients with History of Myocardial Infarction

            Ongoing

            Astra-Zeneca 2011-2013

11.       EPICOR :

            Registre syndromes coronariens aigus.

            Astra Zeneca 2010-2011

12.       trial:

   A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of 
   LCZ696 compared to enalapril on morbidity and mortality in patients with chronic heart failure and
   reduced ejection fraction

           Novartis 2010

13.     CANTOS trial: investigateur principal
          A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous
          canakinumab in theprevention of recurrent cardiovascular events amongstable post-myocardial infarction
          patients with elevated hsCRP

          Ongoing, 2012

          ovartis 2012.

14.     MEDCOR trial:
          Double-blind parallel placebo-controlled study to evaluate the effect of Molsidomine on the
          Endothelial Dysfunction in patients with stable angina pectoris undergoing a percutaneous CORonary intervention.

          Ongoing, 2012

          Therabel Pharma 2012

15.     ODYSSEY  trial, investigateur principal
          A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the
          effect of SAR236553/REGN727 on the Occurrence of Cardiovascular Events in Patients who have Recently
          Experienced an Acute Coronary Syndrome.

          Ongoing 2013-2015

          Sanofi

16.     Ivabradine in HF-PEF, investigateur principal
          Effects of ivabradine versus placebo on cardiac function, exercise capacity, and neuroendocrine activation,
          in patients with Chronic Heart Failure and Preserved left ventricular Ejection Fraction

          2013

          Servier

17.     Paragon:  investigateur principal
          A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and
          safety of LCZ696 compared to valsartan on morbidity and mortality in patients with Chronic heart failure and
          preserved ejection fraction

          Ongoing , 2015

          Novartis

 

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